Ga68 Hot cell positron-emitting radionuclide widely used in PET imaging

Product Detail:

⁶⁸Ga-FAPI (Fibroblast activation imaging)

A hot cell (shielded workstation) is essential for safe ⁶⁸Ga handling, synthesis, and dispensing.

As the application of PET/CT in clinical diagnosis becomes more widespread, the value of positron nuclides is increasingly evident. 68 Ga is currently the most widely used positron nuclide, second only to 18F in its application in PET/CT.

With advent of gallium-labeling somatostatin analogs and its evaluation under positron emission tomography–computed tomography, there has been a tremendous surge in its application. Gallium 68 can be made available either from onsite cyclotron production or in the form of ready-to-use 68Ge/68Ga generators. Wherein setting up and running of cyclotron amounts to huge investment and dedicated team, the 68Ge/68Ga generator has proved to be a better option and viable project. Moreover, due to long half-life of 68Ge, i.e. 271 days, it enables the usage of generator for several months. The preparation of gallium-labeled peptides is much simpler in comparison to 18F radiochemistry, but the radiation exposure has always been an area of concern owing to high-energy annihilation photon of 511 keV.

⁶⁸Ga Production & Source
Source: Typically obtained from a ⁶⁸Ge/⁶⁸Ga generator (half-life: 68 min).

Elution: ⁶⁸Ga is eluted as ⁶⁸GaCl₃ in 0.1M HCl.

Yield: ~1–2 GBq (27–54 mCi) per elution (depends on generator age).

The Gallium-68 shielded hot cell with 2 glove ports ensures the preparation of high energy 68Ga labelled radiopharmaceuticals mainly for PET activity.

Applications

The main uses of hot cells are in the nuclear energy industry and in nuclear medicine, specifically in the production of radiopharmaceuticals. However, they are also used in cleanroom environments for scientific research.